Ranked as the top one pathway, epithelial‐mesenchymal transition (EMT) was found to be highly enriched in E2F7 or E2F8 high‐expression group in HGG (Figure 4A,B), a malignant phenotype transition that confers higher radioresistance to tumor cells.39 Besides, E2F7 and E2F8 were significantly involved with a variety of signaling pathways promoting tumor initiation and progression in HGG, evidenced by the enrichment of NFκB, STAT3, angiogenesis, hypoxia, and glycolysis pathways in high‐expression phenotype (Figure 4A,B). The gene discussed is E2F8; the disease is neoplasm.