E2F1 and cancer: Accumulating evidence has implied that E2Fs were closely linked with tumorigenesis in a variety of cancer types.16, 17, 18 The elevated expression of E2Fs was found to be closely associated with poor prognosis of cancer patients, like pancreatic tumors.19 Among the E2Fs, E2F1 is the most widely investigated member in a huge panel of cancers.