STAT3 and neoplasm: Ranked as the top one pathway, epithelial‐mesenchymal transition (EMT) was found to be highly enriched in E2F7 or E2F8 high‐expression group in HGG (Figure 4A,B), a malignant phenotype transition that confers higher radioresistance to tumor cells.39 Besides, E2F7 and E2F8 were significantly involved with a variety of signaling pathways promoting tumor initiation and progression in HGG, evidenced by the enrichment of NFκB, STAT3, angiogenesis, hypoxia, and glycolysis pathways in high‐expression phenotype (Figure 4A,B).