TNF and stroke disorder: Furthermore, DNT‐intrinsic PTPN2 and FasL may collaboratively regulate the level of M1 microglia via the production of TNF‐α, which amplifies neuroinflammation and exacerbates brain injury after stroke.111 Therefore, infiltrating lymphocytes are critical driving forces for modulating microglia‐mediated neuroinflammation and ischemic brain injury.112 These findings highlight the potential for targeting microglia‐lymphocyte interactions for the development of therapies to reduce CNS insult, including stroke.113