In stroke, DAMPs released by stroke‐affected tissue (neurons, microglia, and astrocytes) and the impaired BBB recruit peripheral immune cells, including neutrophils and lymphocytes, to roll, adhere, aggregate, and infiltrate.100 In addition, activated endothelial cells, microglia, and astrocytes express intercellular adhesion molecule 1 (ICAM‐1) and vascular cell adhesion molecule 1 (VCAM‐1) to help with leukocyte‐endothelial cell adhesion. This evidence concerns the gene ICAM1 and Stroke.