In addition, serum anti‐inflammatory cytokines, including transforming growth factor beta (TGF‐β), interleukin (IL)‐4, and IL‐10, are more prominently upregulated in young mice after middle cerebral artery occlusion (MCAO), whereas proinflammatory cytokines (TNF‐α, iNOS, and IL‐6) are more prominently upregulated in aged mice.19 Therefore, targeting aging microglia or rejuvenating them in stroke patients may represent a promising therapeutic strategy. This evidence concerns the gene TNF and Stroke.