A clinical study of 259 stroke patients demonstrated that higher interleukin‐33 levels are positively correlated with better prognosis.94 However, this conclusion was inconsistent with the findings of another clinical study on 175 patients with aneurysmal subarachnoid hemorrhage (aSAH); this study reported that increases in the level of serum IL‐33 predict a worse prognosis of aSAH.95 Regulating IL‐33/ST2 signaling to promote A2 astrocytes is promising. This evidence concerns the gene IL33 and Stroke.