RYR2 and chronic kidney disease: Ca2+‐induced Ca2+ release (CICR) describes a biological process whereby Ca2+ activates the release of further ionic Ca2+ from SR stores via the RyR to increase [Ca2+]i and aid in the binding of Ca2+ to myofilaments in the initiation of cardiac contraction.23 Our results showed that the ventricular myocytes of CKD mice exhibited decreased Ca2+ transients, prolonged transient decay, increased Ca2+ leak and decreased SR Ca2+ content, which decreased fractional shortening and was arrhythmogenic with more EADs.