RAN and heart failure: A review from Harvath and Bers found that the increased late sodium current also contributed to Ca2+ modulation to cause heart failure, which was associated with increased ROS.29 Our data showed that RAN treatment abrogated CKD‐affected Ca2+ transient, decay time and AP, which suggests that a deterioration of Na+ regulation also modulated intracellular Ca2+ handling in CKD.