In recent years, Xian et al. (Xian & Zhao, 2019) found that KCNQ1OT1 was upregulated in methotrexate‐resistant cells and promoted the methotrexate resistance of CRC cells by regulating miR‐760/PPP1R1B signaling. G. This evidence concerns the gene KCNQ1OT1 and colorectal carcinoma.