These include angioedema (C1 inhibitor [C1-INH] deficiency), kidney and eye diseases (FH, FI or CD46 deficiency), protein-losing enteropathy (CD55 deficiency) and paroxysmal nocturnal hemoglobinuria (PNH) (CD55 + CD59 deficiency) [1, 108, 109]. This evidence concerns the gene CD46 and hyperinsulinemic hypoglycemia, familial, 4.