F2RL1 and cholangiocarcinoma: Another study found no proliferative activity of PAR-2 on pancreatic cells, but a PAR-2 dependent migration of pancreatic cells.53 The same positive association with trypsin and PAR-2 expression has been noted in cholangiocarcinoma cells,54 but not in hepatocellular carcinoma, suggesting tumor tissue specific ways of action and influence.