RSPO4 and neoplasm: Aberrant DNA methylation of some of those top 10 genes with the highest degree has been reported to be associated with neoplasms, such as HHIPL1 (Duong et al., 2012), GABRB2 (Beltrami et al., 2017), FOXF1 (Lo et al., 2010) and RSPO4 (Oka et al., 2009: Figure 2E).