These observations are consistent with our earlier findings on cultured fibroblasts grown without active QSOX1: mechanical stiffness of the ECM in these cultures was impaired, fibronectin matrix was perturbed, adhesion of tumor epithelial cells to the fibroblasts was compromised, and tumor cell migration through the fibroblasts and associated ECM was inhibited [5, 13, 23]. The gene discussed is FN1; the disease is neoplasm.