Our data revealed that the decreased ratios of transcript levels of isoform b versus d or e strongly correlated to higher Gleason score groups (score 6, 7 versus 8–10), which was further supported by the findings that the increased expression levels of PMEPA1 isoforms d and e as well as lower transcript level of PMEPA1-b in tumor tissue compared to normal prostate. The gene discussed is PMEPA1; the disease is neoplasm.