In our experience, TME changed towards a more inflamed environment, evidenced by the increase of cytokines like CXCL10 and CCL2 [35, 36], and the decrease of immunosuppressive molecules (like FoxP3 and Nos2), and molecules that promote tumor growth and invasiveness (like IL10 and TGFβ) [37–39]. Here, NOS2 is linked to neoplasm.