On the other hand, systemic therapy with mCelyvir resulted in non-significant increased mean values of CD8 and CD4 T lymphocytes per tumor volume, expressing markers of recent and sustained T cell activation (OX40 among CD8, PD1 and LAG3 among both CD4 and CD8, and TIM3 among CD4). This evidence concerns the gene TNFRSF4 and neoplasm.