It has been reported that while the combination of YAP1-ZO-2 promotes cell death [46], the combination of YAP2-ZO-2 enhances tumor promoting activity [47] In our immunoprecipitation study, contrary to previous findings, ZO-2 and YAP1 formed a tumor-promoting complex and no ZO-2-YAP2 complex was observed (DNS). The gene discussed is YAP1; the disease is neoplasm.