A significant decrease was found in Apoe−/−IKKε−/− mice infused with Ang II as compared with Apoe−/−mice infused with Ang II (Figure 4(a)), and IKKε deficiency significantly diminished Ang II-induced inflammatory response; studies were performed to assess the expression of several key inflammatory molecules implicated in AAA [12, 13]. Here, APOE is linked to triple-A syndrome.