NFKBIA and colitis: In DSS-induced mice UC, parthenolide (5, 10 and 15 mg/kg) is capable of inhibiting the secretions of TNF-ɑ and IL-1β in colon tissue via blocking the phosphorylation and degradation of IκBα and suppressing the phosphorylation of NF-κBp65, suggesting beneficial effects in experimental colitis [76].