It is reported that paeonol enema (100 μg/mL) treatment improves the symptoms and pathology including body weight, colon length and histological score, and reduces TNF-α-induced NF-κB transactivation and IFNγ-induced STAT1 transactivation in colon cancer-derived CW-2 cells and T cell leukemia-derived jurkat cells, suggesting paeonol enema may be useful for the treatment of colitis [100]. The gene discussed is TNF; the disease is colitis.