As main bioactive compound extracted from Sargentodoxa cuneata, Liriodendrin (100 mg/kg) treatment distinctly improves DAI, colon length and histological damage in colon and suppresses the levels of TNF-a, IL-1β and IL-6 and the activation of Akt and NF-κB pathways, and up-regulates the expression of ERβ in the colon of DSS-induced mouse colitis model. The gene discussed is TNF; the disease is colitis.