In acetic acid-induced colitis model, cardamonin (10 or 30 mg/kg) treatment ameliorates the disease activity index (DAI) and macroscopic damage index scores, and reduces the levels of NF-κB and TNF-α as well as oxidative stress and apoptosis, evidencing it has a protective effect against acetic acid-induced colitis [69]. The gene discussed is NFKB1; the disease is colitis.