In TNBS-induced colitis of rats, ISA (50, 100, 200 mg/kg) treatment not only exerts anti-oxidative and inhibits arachidonic acid actions, but also increases IκBα protein expression and decreases NF-κBp65 protein expression in the colonic mucosa, showing significant therapeutic effects on experimental colitis in rats [70]. This evidence concerns the gene NFKBIA and colitis.