Therefore early detection and breast cancer awareness are the key towards longevity and survival against the disease.9 Previously, genetic alterations in the BRCA1 in Pakistani breast cancer patients have been reported only in two different studies.6,10 The present study was conducted at the Federal Capital Territory so as to comprehend the mutational changes in BRCA1 among the breast cancer patients of the region. The gene discussed is BRCA1; the disease is breast cancer.