Zhang Y et al. reported RKTG to inhibit angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling (Zhang et al., 2010), and MAPK signaling pathway has also been reported to be involved in the development of renal cell carcinoma by some other molecular regulation (Huang et al., 2008; Huang et al., 2016; Li et al., 2017). Here, VEGFA is linked to hereditary clear cell renal cell carcinoma.