Glioma cells deficient for galectin-1 showed reduced tumor growth, increased intra-tumor NK cell infiltration, and elevated expression of granzyme B when implanted into the striatum of Rag1−/− mice (which develop NK, but not T or B cells) when compared to Rag1−/− mice injected with wild-type cells (25). Here, RAG1 is linked to central nervous system cancer.