NCR3LG1 and neoplasm: Using many different human tumor cell lines (pancreatic adenocarcinoma, melanoma, cervical, breast, and hepatocellular carcinomas), Schlecker and colleagues observed that these cells produced B7-H6 at the mRNA level; however they had a low abundance of this protein on the cell membrane compared to what was detectable in the culture supernatant, showing ADAM-10 and 17 cleaving activity (38).