Curiously, several reports have also described the effects of ADAM-17 in cleaving CD16 (FcgRIIIA), one of the most important activating receptors responsible for recognition of antibody-coated target cells and NK cell-mediated ADCC, suggesting the potential for inhibitors of ADAM17 as a novel therapeutic approach to increase NK cell anti-tumor potency during immunotherapy (155). This evidence concerns the gene ADAM17 and neoplasm.