Moreover, a previous study provided conflicting evidence for a pro-inflammatory role of IL-33 in AKI by showing that its application in a mouse model of nephrotoxic AKI induced by the cytostatic drug cisplatin aggravates renal injury (33), suggesting that action of IL-33 and IL-33-induced ILC2s, although not specifically addressed in this study, might be highly context-dependent. Here, IL33 is linked to acute kidney injury.