This Gyc76C-induced cGMP signaling pathway is mediated by the membrane-localized cGMP-dependent protein kinase (cGK) DG2, encoded by the gene dg2 (foraging) and by protein phosphatase 2A, which is crucial for host survival against Gram-positive bacterial infections in Drosophila (Kanoh et al., under revision). The gene discussed is DSC2; the disease is gram-positive bacterial infections.