CXCL2 and neoplasm: In this model, it was shown that ILC2s mediate antitumor activity either by producing cytokines relevant in tumor control (IL-5, IL-13, and GM-CSF) or by producing CXCR2 ligands (CXCL1 and CXCL2), which could induce the apoptosis of CXCR2+ tumor cells (34).