Similar to the changes observed in DPV-infected PBMCs, infection with CHv induced significant increases in the expression of cGAS, STING, RIG-I, MDA5, IRF7, IFN-β, and MX in monocytes/macrophages early, at 6 hpi, but expression rapidly decreased by 12, 24, 48, and 72 hpi (Figure 6), a trend opposite to the growth curve on monocytes/macrophages (Figure 5). The gene discussed is IFNB1; the disease is infection.