In addition, the concentrations of HGF, VEGF, IL-6, and TNF-α were significantly higher in the culture media of peritoneal macrophages treated with LPS from E. coli; this effect was mediated through activation of TLR4; this receptor was also detected in stromal and gland cells from eutopic or ectopic endometrium from endometriosis patients (120). The gene discussed is TNF; the disease is endometriosis.