Recently, to investigate the role of non-genomic activation of ER-β in this disease, a mouse model of surgically induced endometriosis was used through autotransplantation of fragments of endometrial tissue in the peritoneal cavity, both in mice with overexpression of ER-β (ERβ-OE) and in ERβ-null mice. The gene discussed is ESR2; the disease is endometriosis.