In obesity, chronic rise in circulating nutrients such as glucose and free fatty acids (FFAs) resulted in over-expression of IL-1β in pancreatic β-cells (Maedler et al., 2002; Böni-Schnetzler et al., 2008; Fei et al., 2008; Böni-Schnetzler et al., 2009). This evidence concerns the gene IL1B and obesity due to melanocortin 4 receptor deficiency.