Moreover, DCN is able to activate epidermal growth factor receptor (EGFR)‐mediated receptor auto-phosphorylation and downstream signaling pathways, such as the mitogen-activated protein kinase (MARK)1/3 pathway, to mobilize intracellular calcium, and activate other EGFR‐dependent pathways in tumor cells to suppress cell growth (Moscatello et al., 1998; Patel et al., 1998). The gene discussed is EGFR; the disease is neoplasm.