Furthermore, in a progeroid patient carrying two point mutations in beta-1,4-galactosyltransferase 7 (B4GALT7), only 50% of the DCN exhibit GAG side-chain substitution on their core protein, which is thought to be a major mechanistic cause for the skin and wound healing defects observed in this patient with the progeroid form of EDS (Gotte and Kresse, 2005). Here, B4GALT7 is linked to Ehlers-Danlos syndrome.