For instance, in AD where OS is considered a key step in the disease progression, ROS increase the expression of β-secretase through activation of p38 mitogen-activated protein kinase (MAPK) 23 (Giraldo et al., 2014) and increase abnormal tau phosphorylation by activation of glycogen synthase kinase 3, GSK3 (Xiong et al., 2013). Here, MAPT is linked to Alzheimer disease.