Moreover, analysis from TCGA-SKCM database showed that melanoma patients with high expression of CACNA1H have a worse survival outcome compared with those with low CACNA1H expression (p = 0.029) (Supplementary Fig. S4a) Furthermore, we confirmed that Cacna1h was highly expressed in both C790 and 4434 partially reprogrammed cells (Fig. 3e and Supplementary Fig. S4b), highlighting the importance of calcium in adaptation to MAPKi. This evidence concerns the gene CACNA1H and melanoma.