Our findings are consistent with those of a smaller study of 191 adults, which reported higher levels of CRP during the febrile phase of illness in severe versus non-severe dengue (defined using 2009 WHO classification) (AUC 0.938 at a CRP threshold of 30.1 mg/L; 100% sensitivity, 76.3% specificity) [5]. The gene discussed is CRP; the disease is dengue disease.