This prospective, multicenter study derived and validated an sFlt-1/PlGF ratio of ≤38 for ruling out preeclampsia within 1 week—in the validation arm, a cutoff of ≤38 provided a negative predictive value (NPV) of 99.3% (Table 2).25 The clinical utility of the sFlt-1/PlGF ratio cutoff of 38 for short-term prediction of preeclampsia was validated in 764 Asian pregnant women with suspected preeclampsia in PROGNOSIS Asia. This evidence concerns the gene PGF and preeclampsia.