The growing understanding of preeclampsia as a heterogeneous hypertensive disorder of pregnancy triggered the ACOG’s hypertension 2013 task force to revise the definition of preeclampsia to include the presence of severe features with or without proteinuria (Table 1).10,13 Clinical and pathological studies suggest that the placenta plays a central role in the pathogenesis of preeclampsia.67 Altered angiogenic biomarkers (sFlt-1/PlGF ratio or PlGF alone) are indicative of PD. The gene discussed is PGF; the disease is preeclampsia.