Combined analysis of uterine Doppler and angiogenic factors substantially improves sensitivity and specificity for prediction of adverse outcomes and iatrogenic preterm delivery.42,56–61 Stepan et al58 observed significantly higher sFlt-1 (1403.6±555 versus 451.8±42 pg/mL; P<0.05) and lower PlGF (139.6±24 versus 184.1±21 pg/mL) concentrations in second-trimester pregnancies with adverse versus normal outcomes—this difference was more pronounced in patients with subsequent preeclampsia than subsequent FGR due to greater decrease in PlGF in preeclampsia. Here, PGF is linked to preeclampsia.