RESLES lesions have been described in infections, the use and withdrawal of antiepileptic drugs, in alcoholism and in hypoglycemia, all of which have been related to ADH and AVP. (Figure 2) In a literature review, Garcia-Monco et al. found 38 patients with RESLES with an encephalopathy in the setting of a systemic infection, without CSF parameters of infection and without seizures or AED treatment. The gene discussed is AVP; the disease is alcohol dependence.