These findings raise many questions, such as “what are the most important metabolites that relay inflammation or inflammatory markers and the kynurenine pathway in schizophrenia?” For example, in an animal model of pregnant rats, the deletion of one allele for KMO (KMO+/−) in the maternal genetic material brought to a disproportionate KYNA increase in the brain of KMO+/− offspring rats, compared to KMO wild-type offspring rats (KMO+/+) [84]. Here, KMO is linked to schizophrenia.