ARG1 and cancer: In an extensive study, Kaneda et al. [58] demonstrated that TAMs exploited numerous mechanisms to drive PDAC progression, including secreting immunosuppressive factors such as arginase-1 (Arg1) and TGF-β to inhibit antitumour CD8+ T cells and promoting PDAC desmoplasia and cancer cell metastasis via the chemotactic factor PDGF-BB.