Aberrant expression of circRNAs played vital roles in proliferation, cell cycle, invasion and metastasis of glioma through modulating complementary miRNAs or target mRNAs that were firmly related to cancer-associated signaling pathways, such as PI3K/AK/mTOR, Wnt/β-catenin, Notch pathways. This evidence concerns the gene MTOR and central nervous system cancer.