AKT1 and glioblastoma: CircNT5E consists of 7 exons (exons 3–9) from the NE5E genome, affected apoptosis, invasion, and migration abilities of glioblastoma cells via sponging miR-422a, subsequently up-regulating the NT5E, SOX4, PI3KCA, p-Akt, and p-Smad2 levels.