circCPA4, circSCAF11, circ-PITX1 were significantly up-regulated in GBM, accelerated the glioma tumorigenesis via let7/CPA4, miR421/SP1/VEGFA, miR-379-5p/MAP3K2 axis, respectively [87–89], while CircMTO1 markedly down-regulated and inhibited GBM proliferation through miR92/WWOX pathway [90]. This evidence concerns the gene SP1 and glioblastoma.