However, the synaptic protein level of GluA2 (GluA2‐SP) was significantly decreased in APP23/PS45 mice (AD + AAVEGFP: 88.02 ± 1.46% relative to WT, p = .043 vs. WT; Figure 3d) compared to the WT group. This evidence concerns the gene GRIA2 and Alzheimer disease.