We here further found that TRPV1 upregulation by AAVTRPV1 could significantly ameliorate anxiety‐ and depression‐like behaviors in APP23/PS45 mice during the elevated plus maze (Figure 2a and b), three‐chambered social interaction (Figure 2c), and force swimming tests (Figure 2d). This evidence concerns the gene TRPV1 and major depressive disorder.