The results from long‐term spatial memory retrieval test revealed that treatment with CAP (AD + CAP: 6.86 ± 1.61, p = .490 vs. WT, p = .004 vs. AD; Figure 6b), but not CPZ (AD + CPZ: 1.63 ± 0.80 s, p = .003 vs. WT, p = .368 vs. AD; Figure 6b), reversed the memory decline in APP23/PS45 mice since the number of entries into the platform zone was dramatically increased, compared to vehicle treatment. The gene discussed is CPZ; the disease is Alzheimer disease.