The results showed that the level of TRPV1 protein was significantly reduced in the brain of APP23/PS45 double transgenic AD model mice at the age of 4 months (AD: 40.65 ± 11.66% relative to WT, p < .001 vs. WT; Figure 1a), compared with the age‐matched wild‐type (WT) littermates. Here, TRPV1 is linked to Alzheimer disease.