Upregulation of TRPV1 could reverse the LTP impairment (AD + AAVTRPV1: n = 6 slices from 4 mice, 203.46 ± 17.22% baseline, p < .001 vs. AD + AAVEGFP; Figure 2), whereas AAVshTRPV1 treatment had no effect on LTP induction (AD + AAVshTRPV1: n = 6 slices from 4 mice, 139.17 ± 14.29% baseline, p = .324 vs. AD + AAVEGFP; Figure 2) in APP23/PS45 mice. This evidence concerns the gene TRPV1 and Alzheimer disease.