BACE1 and Alzheimer disease: For instance, the levels of calcium activity are increased in AD patients (Johnson et al., 1997) and elevated Ca2+ induce BACE1 expression and consequently result in an increase in Aβ production (Cho, Jin, Youn, Huh, & Mook‐Jung, 2008; Mata, 2018) and cell death (Pierrot, Ghisdal, Caumont, & Octave, 2004).