We here further found that TRPV1 upregulation by AAVTRPV1 could significantly ameliorate anxiety‐ and depression‐like behaviors in APP23/PS45 mice during the elevated plus maze (Figure 2a and b), three‐chambered social interaction (Figure 2c), and force swimming tests (Figure 2d). The gene discussed is TRPV1; the disease is depressive disorder.