In recent years, accumulating studies have focused on the genetic polymorphisms of immune molecules with susceptibility to the various tumors, including BTLA. 12, 13, 14, 15 Fu et al12 genotyped five SNPs and found that BTLA rs1844089, rs2705535, and rs2633562 polymorphisms were associated with the pathological features of breast cancer. The gene discussed is BTLA; the disease is breast carcinoma.