GJA4 and asthma: Furthermore, some genes previously found in blood-based EWAS were confirmed in the nasal cells including ACOT7, EPX, GJA4, and METTL1. A predictive model based on DNA methylation changes of 30 CpGs in nasal cells showed improved performance compared to the Asthma Predictive Index to predict development of asthma in children with wheeze [28].