In rat models of kidney injury induced by auranofin, nephrotoxic serum injection, or unilateral ureteral obstruction, pre-treatment with the ASK1 inhibitor GS-444217 (30 mg/kg via oral gavage) suppresses the ROS-ASK1-P38/JNK response [59, 60]. The gene discussed is MAP3K5; the disease is Ureteral obstruction.