PHF19 and plasma cell myeloma: Analysis of top-performing methods identified high expression of PHF19, a histone methyltransferase, as the gene with the strongest association with myeloma progression, with greater predictive power than the expression level of the known high-risk gene MMSET. We developed a four-parameter model using age, ISS, and PHF19 and MMSET expression that performs as well as more complex models having many more gene features.