To our knowledge, this is the largest phase II study on the use of a PI3K inhibitor in patients with DLBCL; therefore, further exploration of copanlisib in combination with other targeted therapies (e.g., a Bruton’s tyrosine kinase inhibitor [14] or a BCL2 antagonist [15]) or in molecularly defined subgroups of DLBCL is warranted. The gene discussed is BCL2; the disease is diffuse large B-cell lymphoma.