Another study described four prominent genetic subtypes in DLBCL, termed MCD (based on the co-occurrence of MYD88L265P and CD79B mutations), BN2 (based on BCL6 fusions and NOTCH2 mutations), N1 (based on NOTCH1 mutations), and EZB (based on EZH2 mutations and BCL2 translocations), using exome and transcriptome sequencing, array-based DNA copy-number analysis, and targeted amplicon resequencing [29]. The gene discussed is NOTCH2; the disease is diffuse large B-cell lymphoma.