In contrast to what was observed in Atm−/− background (Fig. 2a, b), loss of functional TDP2 did not significantly decrease lifespan (Fig. 2e), nor increase the high incidence of cancer (Supplementary Fig. 2e), and thymic lymphoma in particular (Fig. 2f), observed in Trp53−/− animals. This evidence concerns the gene TP53 and thymus lymphoma.