Combined treatment by CBD (20 μM) and AG490 (20 μM) or by CBD and STAT3 inhibitor-6 (40 μM) resulted in an additional downregulation of survival of U87MG cells (Fig. 4h) highlighting a role of the JAK2-STAT3-P pathway as a general pro-survival factor in GBM cells before and after CBD treatment. Here, STAT3 is linked to glioblastoma.