IKBKB and glioblastoma: NF-κB p65 phosphorylation/activation was markedly reduced by a combination of small molecule inhibitors of IKKβ (BMS345541 at 10 μM) and PI3K-AKT (LY294002 at 40 μM), because both pathways were involved in IκBα phosphorylation-degradation in GBM cells28.