NFKB1 and neoplasm: Of note, IL-17-stimulated Ls174t cell line that expressed an enzymatically defective caspase-3 mutant (C163A) remained susceptible to TTM treatment-induced reduction in Ki67+ cells and suppression of tumor growth (Supplementary Fig. 5a–g), highlighting a caspase-3-independent impact of STEAP4 on NFκB in promoting tumor growth.