Histopathological review of adrenal gland and paravertebral sympathetic ganglia from LSL-MYCN;Dbh-iCre and AtrxLox/Lox;LSL-MYCN;Dbh-iCre mice at 3 weeks and 1 year of age showed no differences (Supplementary Fig. 2, Supplementary Note 2), suggesting that the lack of tumor formation was not due to death of the NB cell of origin. The gene discussed is MYCN; the disease is neoplasm.