PNPT1 and cancer: These upregulated target genes are enriched for the pathways involved in metabolism (e.g., SLC3A2, SLC7A5) and mitochondrial gene expression (e.g., PNPT1) (Fig. 3f, g, Supplementary Fig. 6B-E, and Data 7), consistent with previous studies, demonstrating that elevated MYC/MYCN induces metabolic reprogramming in cancer cells11.