In summary, our data implicate a Dgcr8–miR-382-3p/miR-674-3p–Drd1 pathogenic mechanism of slower ciliary beating and ventricular enlargement in 22q11DS, a rare disease that substantially increases the risk of several neuropsychiatric disorders including SCZ. The gene discussed is DGCR8; the disease is 22q11.2 deletion syndrome.