However, in the normal cell model (C2C12), CASZ1 regulates gene sets associated with repression of oligodendrocyte differentiation, telomere maintenance and chromosome maintenance, while in the tumor model (SMS-CTR cells) the top regulated gene sets are involved in breast cancer development, colorectal cancer development, cervical cancer proliferation (Supplementary Data 8). The gene discussed is CASZ1; the disease is colorectal cancer.