In agreement with previously reported data27,28, miR-378a-5p induced a significant increase of VEGF secretion in melanoma cells while, contrary to the evidence that miR-378a-5p increases the expression of IL-828, the cytokine was found to be equally secreted in control and miR-378a-5p overexpressing melanoma cells, thus indicating a cell-type specific effect. Here, VEGFA is linked to melanoma.