HOXD10 and melanoma: HOXD10 relevance in melanoma progression and its involvement in miR-378a-5p mediated functions is strongly supported by: (i) the lower level of HOXD10 transcript in metastatic melanoma samples compared to primary ones observed in a TCGA dataset, (ii) the negative correlation between miR-378a-5p and HOXD10 expression levels observed in a TCGA dataset of a melanoma patient cohort, (iii) the role played by HOXD10 in the regulation of MMP240 and in maintaining a non-angiogenic state in the endothelium31.