MMP2 and melanoma: As observed in other tumor histotypes13,25, miR-378a-5p overexpression induced a significant increase of both migratory and invasive capacity of M14, A375, and SBCL1 melanoma cells (Fig. 2a, Supplementary Fig. 3), as well as an increased expression of Metalloprotease-2 (MMP2) (Fig. 2b), which is a key metalloprotease involved in melanoma progression.