In agreement with previously published papers14,19,23 our results confirmed miR-378a-5p ability to negatively regulate the expression of KLF9, FUS-1, and SUFU, transcription factors with tumor suppression function, involved in cell survival, growth, and angiogenesis of several cancer models not including melanoma14,15,23,25. The gene discussed is KLF9; the disease is neoplasm.