To determine the clinical relevance of our finding that OGT inhibits hypoxia-induced PFKFB3-S172 phosphorylation, we performed IHC to analyze OGT and PFKFB3 pSer172 levels in 73 human pancreatic tumor specimens with validation of the antibody (Fig. 6c and Fig. S6). The gene discussed is PFKFB3; the disease is pancreatic neoplasm.