BLM and Bloom syndrome: To identify metabolic pathways that are modulated by autophagy in AT2 cells during BLM-induced lung injury, RNA-seq and metabolic profiling were carried out with AT2 cells from Atg5f/f mice treated with PBS (AT2), Atg5f/f mice treated with BLM (AT2-BLM), and Nkx2. 1Cre;Atg5f/f mice treated with BLM (Atg5−/− AT2-BLM) at day 14.