One child developed an episode of liver dysfunction with massively elevated transaminase activities (AST 4150 IU/L, ALT 2200 IU/L) at age 5 months [22], and another patient showed an AST activity of 11,736 IU/l during a severe metabolic decompensation at age 7 months [23]. The gene discussed is GPT; the disease is Decreased liver function.