Therefore, we investigated gene expression of Transforming growth factor beta 1 (Tgf-β1), Collagen, type I, alpha 1 (Col1a1) and Laminin. TGF-β1 as one member of the TGF-β superfamily was identified as a central mediator in renal fibrosis [30]. This evidence concerns the gene COL1A1 and renal fibrosis.