In our previous studies on atherosclerotic animal models and in patients with hypertension and dyslipidemia, we showed that treatment with irbesartan, an AT1 receptor antagonist, diminished total MV levels in peripheral blood, especially specific MVs (leukocyte-, platelet-, and endothelial-derived MVs), and increased EPC levels, thereby preventing the development of vascular endothelial dysfunction by the augmentation of endothelium-mediated vasodilation [38,42,43,44]. The gene discussed is AGTR1; the disease is Hypertension.