According to the pathological analysis, glomerular necrosis, glomerulosclerosis, interstitial infiltration, tubular atrophy, vasculitis, and macrophage infiltration, shown by staining with an anti-F4/80 antibody, were dramatically reduced in the IL-17A vaccine group compared to the saline group 36 weeks after vaccination (Figure 4b,c). The gene discussed is IL17A; the disease is glomerulosclerosis.